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We'd like to understand how you use our websites in order to improve them. Register your interest. A second haemolytic crisis of blackwater fever BWF following a combination of artemether-lumefantrine intake, in an 8-year-old Congolese boy is reported. The patient had a history of BWF after quinine intake. He was given artemether-lumefantrine treatment for malaria. He was free from G6PD deficiency and abnormal haemoglobin. Sepsis was eliminated. Haemolysis was noted with 5. Low-level Plasmodium falciparum was found.

The outcome was favourable with rehydration. BWF has been described with quinine, mefloquine and halofantrine. Several case reports have been published of haemolysis after lumefantrine, but it is quite rare. This case has a major therapeutic implication: aryl-amino-alcohol should be strictly contraindicated in patients with history of BWF with aryl-amino-alcohols intake.

This is a preview of subscription content, log in to check access. Bakshi R, Hermeling-Fritz I, Gathmann I, Alteri E An integrated assessment of the clinical safety of artemether-lumefantrine: a new oral fixed-dose combination antimalarial drug. Trop Med Int Health 4 1 —3. Presse Med 31 28 — Trois observations. Presse Med 22 2 Bull Soc Pathol Exot 97 5 —8.

Lancet —9. Arch Pediatr 14 8 —5 [Epub May 23]. Rogier C, Imbert P, Tall A, et al Epidemiological and clinical aspects of blackwater fever among African children suffering frequent malaria attacks. Staedke SG, Mwebaza N, Kamya MR, et al Home management of malaria with artemether-lumefantrine compared with standard care in urban Ugandan children: a randomised controlled trial.

Lancet — Van den Ende J, Coppens G, Verstraeten T, et al Recurrence of blackwater fever: triggering of relapses by different antimalarials. Trop Med Int Health 3 8 —9. Wernsdorfer WH Coartemether artemether and lumefantrine : an oral antimalarial drug. Expert Rev Anti Infect Ther 2 2 — White NJ Malaria. Saunders, London, pp — Google Scholar. Download references. Correspondence to N. Aloni, N. Download citation. Received : 01 July Accepted : 01 June Published : 23 July Issue Date : December Search SpringerLink Search.

Abstract A second haemolytic crisis of blackwater fever BWF following a combination of artemether-lumefantrine intake, in an 8-year-old Congolese boy is reported. Muanda Authors N. Aloni View author publications. You can also search for this author in PubMed Google Scholar. View author publications.

About this article Cite this article Aloni, N.


Hémolyse intravasculaire après prise d’artéméther-luméfantrine

Severe hemolytic anemia is an unusual complication of Wilson's disease. Blood smear analysis showed stippled red cells in one case; hemolytic anemia improved within a few weeks in both patients but progressive liver failure required transplantation in the other. Hemolysis probably results from the toxic effect of free serum copper on erythrocyte membrane. Previous Article La pelade est-elle une maladie psychosomatique? Misery, H.

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